Gene name:
HLA-DMA(DMA;RING6);
Protein name:
HLA class II histocompatibility antigen, DM alpha chain;
Alternative:
Really interesting new gene 6 protein;MHC class II antigen DMA;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of an alpha chain (DMA) and a beta chain (DMB).
Function:
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Subcellular Location:
Late endosome membrane
Single-pass type I membrane protein
Lysosome membrane
Single-pass type I membrane protein
Localizes to late endocytic compartment. Associates with lysosome membranes.
Protein Attributes:
50:
MGHEQNQGAA | LLQMLPLLWL | LPHSWAVPEA | PTPMWPDDLQ | NHTFLHTVYC |
100:
QDGSPSVGLS | EAYDEDQLFF | FDFSQNTRVP | RLPEFADWAQ | EQGDAPAILF |
150:
DKEFCEWMIQ | QIGPKLDGKI | PVSRGFPIAE | VFTLKPLEFG | KPNTLVCFVS |
200:
NLFPPMLTVN | WHDHSVPVEG | FGPTFVSAVD | GLSFQAFSYL | NFTPEPSDIF |
250:
SCIVTHEIDR | YTAIAYWVPR | NALPSDLLEN | VLCGVAFGLG | VLGIIVGIVL |
Vaild Sequence:
Related Databases
Uniprot:
